Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Targeting Neurohormonal Activation in Pulmonary Arterial Hypertension
SEE PAGE 22 P ulmonary artery hypertension (PAH) is an angioproliferative disorder of the lung circulation that results in a heart failure syndrome with a grim prognosis (1). Similar to other forms of left ventricular failure, right ventricular failure (RVF) is progressive and largely incurable unless the primary cause can be eliminated (i.e., lung transplantation for PAH). Although pressure ov...
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Pulmonary artery smooth muscle cells (PASMC), in pulmonary arterial hypertension (PAH), contribute to obliterative vascular remodelling and are characterised by enhanced proliferation, suppressed apoptosis and, a much less studied, increased migration potential. One of the major proteins that regulate cell migration is focal adhesion kinase (FAK), but its role in PAH is not fully understood. We...
متن کاملTHE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION
The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurem...
متن کاملTargeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension.
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death. Vascular remodeling is the key pathological feature of PAH, but treatments targeting this process are lacking. In this review, we summarize importa...
متن کاملActivated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.
AIMS Pulmonary arterial hypertension (PAH) is a progressive lung disease characterized by pulmonary vasoconstriction and vascular remodelling, leading to increased pulmonary vascular resistance and right heart failure. Loss of nitric oxide (NO) signalling and increased endothelial nitric oxide synthase (eNOS)-derived oxidative stress are central to the pathogenesis of PAH, yet the mechanisms in...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2011
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2011.02.032